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KMID : 1094020060230040465
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Journal of Veterinary Clinics
2006 Volume.23 No. 4 p.465 ~ p.468
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Acute Fulminating Myasthenia Gravis in a Shih-tzu Dog
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Kang Byeong-Teck
Yoo Jong-Hyun
Park Hyo-Jin
Jung Dong-In
Park Chul
Gu Su-Hyun
Jeon Hyo-Won
Kim Ju-Won
Kim Ha-Jung
Lim Chae-Young
Cho Sue-Kyung
Lee So-Young
Heo Ra-Young
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Abstract
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A 3-year-old, spayed female Shih-tzu dog was presented due to acute vomiting, diarrhea, and generalized weakness. The dog had generalized weakness, increased respiratory rate, and respiratory muscle effect. Neurologic examination revealed appendicular muscular weakness and decreased in tone of the anal sphincter. Megaesophagus was confirmed by radiographic examinations. Other than type 2 fiber atrophy, no specific abnormalities were identified in histopathologic examinations of muscle biopsies from the left pelvic limb. Serum acetylcholine receptor (AChR) antibody titer was increased (0.78 nmol/L reference range, less than 0.6 nmol/L), confirming a diagnosis of acute fulminating myasthenia gravis. The dog dramatically responded to pyridostigmine bromide and had marked improvement in muscle strength, megaesophagus, and respiratory function. The dog has been successfully managed for 7 months after initial treatment.
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KEYWORD
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acetylcholine receptor (AChR) antibody titer, acute fulminating myasthenia gravis, megaesophagus, type 2 fiber atrophy
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